As the clock speed in computer Central Processing Units (CPUs) began to plateau, their data and task parallelism was expanded to compensate. These days (2013) it is not uncommon to find upwards of a dozen processing cores on a single CPU and each core capable of performing 8 calculations as a single operation. Graphics Processing Units were originally intended to assist CPUs by providing hardware optimised to speed up rendering highly parallel graphical data into a frame buffer. As graphical models became more complex, it became difficult to provide a single piece of hardware which implemented an optimised design for every model and every calculation the end user may desire. Instead, GPU designs evolved to be more readily programmable and exhibit greater parallelism. Top-end GPUs are now equipped with over 2,500 simple cores and have their own CUDA or OpenCL programming languages. This new found programmability allowed users the freedom to take non-graphics tasks which would otherwise have saturated a CPU for days and to run them on the highly parallel hardware of the GPU. This technique proved so effective for certain tasks that GPU manufacturers have since begun to tweak their architectures to be suitable not just for graphics processing but also for more general purpose tasks, thus beginning the evolution General Purpose Graphics Processing Unit (GPGPU).
Improvements in data capture and model generation have caused an explosion in the amount of bioinformatic data which is now available. Data which is increasing in volume faster than CPUs are increasing in either speed or parallelism. An example of this can be found here, which displays a graph of the number of proteins stored in the Protein Data Bank per year. To process this vast volume of data, many of the common tools for structure prediction, sequence analysis, molecular dynamics and so forth have now been ported to the GPGPU. The following tools are now GPGPU enabled and offer significant speed-up compared to their CPU-based counterparts:
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